Gene name:
Pcgf6 (Mblr;Rnf134) ;
Protein name:
Polycomb group RING finger protein 6 ;
Alternative:
RING finger protein 134 ;Mel18 and Bmi1-like RING finger ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of a PRC1-like complex. Interacts with BMI1/PCGF4, RING1 and RNF2. Interacts with KDM5D. Interacts with CBX4, CBX6, CBX7 and CBX8.
Function:
Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MDEAETDATE | NKRASEAKRA | SAMPPPPPPP | PPISPPALIP | APAAGEEGPA |
100:
SLGQAGAAGC | SRSRPPALEP | ERSLGRLRGR | FEDYDEELEE | EEEMEEEEEE |
150:
EEEMSHFSLR | LESGRADSED | EEERLINLVE | LTPYILCSIC | KGYLIDATTI |
200:
TECLHTFCKS | CIVRHFYYSN | RCPKCNIVVH | QTQPLYNIRL | DRQLQDIVYK |
250:
LVINLEEREK | KQMHDFYKER | GLEVPKPAAP | QPVPSSKGKT | KKVLESVFRI |
300:
PPELDMSLLL | EFIGANEDTG | HFKPLEKKFV | RVSGEATIGH | VEKFLRRKMG |
350:
LDPACQVDII | CGDHLLERYQ | TLREIRRAIG | DTAMQDGLLV | LHYGLVVSPL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Mouse Polycomb group RING finger protein 6
ELISA Kit for Mouse Polycomb group RING finger protein 6
ELISA Kit for Mouse Polycomb group RING finger protein 6
CLIA Kit for Mouse Polycomb group RING finger protein 6
CLIA Kit for Mouse Polycomb group RING finger protein 6
CLIA Kit for Mouse Polycomb group RING finger protein 6
Polyclonal Antibody for Mouse Polycomb group RING finger protein 6
Polyclonal Antibody for Mouse Polycomb group RING finger protein 6
Polyclonal Antibody for Mouse Polycomb group RING finger protein 6
Monoclonal Antibody for Mouse Polycomb group RING finger protein 6
Monoclonal Antibody for Mouse Polycomb group RING finger protein 6
Monoclonal Antibody for Mouse Polycomb group RING finger protein 6
Protein for Mouse Polycomb group RING finger protein 6
Protein for Mouse Polycomb group RING finger protein 6
Protein for Mouse Polycomb group RING finger protein 6
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
tissue :
Thymus .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
strain :
FVB/N .
tissue :
Brain .
tissue :
Mammary tumor .